Wang Hui's Lab

Peking University Health Science Center
Peking University People’s Hospital

研究成果 (Research findings)

研究论文 (Publications)：

Yin Y, Zhu P, Guo Y, Li Y, Chen H, Liu J, Sun L, Ma S, Hu C, Wang H*. Enhancing lower respiratory tract infection diagnosis: implementation and clinical assessment of multiplex PCR-based and hybrid capture-based targeted next-generation sequencing. EBioMedicine. 2024 Sep;107:105307.
Chen H, Qi T, Guo S, Zhang X, Zhan M, Liu S, Yin Y, Guo Y, Zhang Y, Zhao C, Wang X, Wang H*. Integrating respiratory microbiome and host immune response through machine learning for respiratory tract infection diagnosis. NPJ Biofilms Microbiomes. 2024 Sep 12;10(1):83.
Song K, Jin L, Cai M, Wang Q, Wu X, Wang S, Sun S, Wang R, Chen F, Wang H*. Decoding the origins, spread, and global risks of mcr-9 gene. EBioMedicine. 2024 Sep 10;108:105326.
Cai M, Song K, Wang R, Wang S, Chen H, Wang H*. Tracking intra-species and inter-genus transmission of KPC through global plasmids mining. Cell Rep. 2024 Jun 25;43(6):114351.
Chen H, Zhan M, Liu S, Balloux F, Wang H*. Unraveling the potential of metagenomic next-generation sequencing in infectious disease diagnosis: Challenges and prospects. Sci Bull (Beijing). Published online April 16, 2024.
Wang Q, Wang R, Wang S, Zhang A, Duan Q, Sun S, Jin L, Wang X, Zhang Y, Wang C, Kang H, Zhang Z, Liao K, Guo Y, Jin L, Liu Z, Yang C, Wang H*. China Carbapenem-Resistant Enterobacterales (CRE) Network. Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: An epidemiological, spatial, genomic analysis. Drug Resist Updat. 2024 May;74:101083.
Sun L, Mi S, Fan C, Guo Y, Wang H*. Anchovy-like fluid drained from a huge liver abscess: A diagnostic challenge. Travel Med Infect Dis. 2024 Mar-Apr;58:102705
Zheng J, Chen S, Song M, Liu B, Ma S, Wang S, Wang Q, Ding Q, Xia Q, Zhu K, Wang H*. Discovery of adjuvants with antibacterial potentiation activity against carbapenemase-producing Enterobacterales based on in silico virtual screening. Int J Antimicrob Agents. 2024 Feb;63(2):107076.
Chen F, Yin Y, Chen H, Wang R, Wang S, Wang H*. Global genetic diversity and Asian clades evolution: a phylogeographic study of Staphylococcus aureus sequence type 5. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0117523.
Sun S, Cai M, Wang Q, Wang S, Zhang L, Wang H*. Emergency of the plasmid co-carrying bla_KPC-2 and bla_NDM-1 genes in carbapenem-resistant hypervirulent Klebsiella pneumoniae. J Glob Antimicrob Resist. 2024 Mar;36:26-32.
Wang R, Zhang A, Sun S, Yin G, Wu X, Ding Q, Wang Q, Chen F, Wang S, van Dorp L, Zhang Y, Jin L, Wang X, Balloux F, Wang H*. Increase in antioxidant capacity associated with the successful subclone of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11-KL64. Nat Commun. 2024 Jan 2;15(1):67.
Chen H, Zheng Y, Zhang X, Liu S, Yin Y, Guo Y, Wang X, Zhang Y, Zhao C, Gai W, Wang H*. Clinical evaluation of cell-free and cellular metagenomic next-generation sequencing of infected body fluids. J Adv Res. 2024 Jan;55:119-129.
Liu S, Chen H, Xu F, Chen F, Yin Y, Zhang X, Tu S, Wang H*. Unravelling staphylococcal small-colony variants in cardiac implantable electronic device infections: clinical characteristics, management, and genomic insights. Front Cell Infect Microbiol. 2024 Jan 8;13:1321626.
Gao Y, Li H, Zhao C, Li S, Yin G, Wang H*. Machine learning and feature extraction for rapid antimicrobial resistance prediction of Acinetobacter baumannii from whole-genome sequencing data. Front Microbiol. 2024 Jan 11;14:1320312.
Yin G, Guo Y, Ding Q, Ma S, Chen F, Wang Q, Chen H, Wang H*. Klebsiella quasipneumoniae in intestine damages bile acid metabolism in hematopoietic stem cell transplantation patients with bloodstream infection. J Transl Med. 2023 Mar 29;21(1):230.
Chen H#, Zheng Y#, Zhang X, Liu S, Yin Y, Guo Y, Wang X, Zhang Y, Zhao C, Gai W*, Wang H*. Clinical evaluation of cell-free and cellular metagenomic next-generation sequencing of infected body fluids. J Adv Res. 2023 Mar 6:S2090-1232(23)00068-1.
Liu S#, Chen H#*, Chen J, Wang T, Tu S, Zhang X, Wang Q, Yin Y, Zhang Y, Wang X, Zhao C, Wang H*. Transcriptome and Proteome of Methicillin-Resistant Staphylococcus aureus Small-Colony Variants Reveal Changed Metabolism and Increased Immune Evasion. Microbiol Spectr. 2023 Feb 14:e0189822.
Wang H*. Current and Future Landscape of the Antimicrobial Resistance of Nosocomial Infections in China. China CDC Wkly. 2022 Dec 9;4(49):1101-1104.
Wang Z, Fan X, Wang S, Li S, Gao Y, Wang H, Li H*. Emergence of Colistin-Resistant Acinetobacter junii in China. Antibiotics (Basel). 2022 Nov 24;11(12):1693.
Chen F, Yin Y, Chen H, Jin L, Li S, Wang R, Wang S, Wang Q, Sun S, Wang H*. Phenotypic and Genomic Comparison of Staphylococcus aureus Highlight Virulence and Host Adaptation Favoring the Success of Epidemic Clones. mSystems. 2022 Dec 20;7(6):e0083122.
Zhang P#, Wang Q#, Zhou C, Zhang F, Gao X, Tenover FC, Tang YW, Wang H*. A Pooling Strategy for Detecting Carbapenem Resistance Genes by the Xpert Carba-R Test in Rectal Swab Specimens. J Clin Microbiol. 2022 Dec 21;60(12):e0118122.
Duan Q#, Wang Q#, Sun S, Cui Q, Ding Q, Wang R, Wang H*. ST11 Carbapenem-Resistant Klebsiella pneumoniae Clone Harboring blaNDM Replaced a blaKPC Clone in a Tertiary Hospital in China. Antibiotics (Basel). 2022 Oct 7;11(10):1373.
Lo SW*, Mellor K, Cohen R, Alonso AR, Belman S, Kumar N, Hawkins PA, Gladstone RA, von Gottberg A, Veeraraghavan B, Ravikumar KL, Kandasamy R, Pollard SAJ, Saha SK, Bigogo G, Antonio M, Kwambana-Adams B, Mirza S, Shakoor S, Nisar I, Cornick JE, Lehmann D, Ford RL, Sigauque B, Turner P, Moïsi J, Obaro SK, Dagan R, Diawara I, Skoczyńska A, Wang H, Carter PE, Klugman KP, Rodgers G, Breiman RF, McGee L, Bentley SD, Muñoz-Almagro C, Varon E; Global Pneumococcal Sequencing Consortium. Emergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole-genome sequencing study. Lancet Microbe. 2022 Oct;3(10):e735-e743.
Jia Y, Zhang J, Zhao Y, Dong R, Wang H, Jiang X*. Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria. Chem Commun (Camb). 2022 Sep 20;58(75):10544-10547.
Wang S#, Ding Q#, Zhang Y, Zhang A, Wang Q, Wang R, Wang X, Jin L, Ma S, Wang H*. Evolution of Virulence, Fitness, and Carbapenem Resistance Transmission in ST23 Hypervirulent Klebsiella pneumoniae with the Capsular Polysaccharide Synthesis Gene wcaJ Inserted via Insertion Sequence Elements. Microbiol Spectr. 2022 Dec 21;10(6):e0240022.
Zhao C, Yang S, Zhang F, Wang Z, Zhang Y, Wang X, Li H, Chen H, Wang H*. Antimicrobial Resistance Trends of the Most Common Causative Pathogens Associated with Community-acquired Respiratory Infections in China: 2009-2018. Infect Drug Resist. 2022 Aug 31;15:5069-5083.
Chen H, Li M, Tu S, Zhang X, Wang X, Zhang Y, Zhao C, Guo Y, Wang H*. Metagenomic data from cerebrospinal fluid permits tracing the origin and spread of Neisseria meningitidis CC4821 in China. Commun Biol. 2022 Aug 18;5(1):839.
Cao LL, Han Y, Pei L, Yue ZH, Liu BY, Cui JW, Jia M, Wang H*. A Serum Metabolite Classifier for the Early Detection of Type 2 Diabetes Mellitus-Positive Hepatocellular Cancer. Metabolites. 2022 Jul 1;12(7):610.
Gao Y, Li H, Chen H, Zhang J, Wang R, Wang Z, Wang H*. Origin, Phylogeny, and Transmission of the Epidemic Clone ST208 of Carbapenem-Resistant Acinetobacter baumannii on a Global Scale. Microbiol Spectr. 2022 Jun 29;10(3):e0260421.
Wang Q, Jin L, Sun S, Yin Y, Wang R, Chen F, Wang X, Zhang Y, Hou J, Zhang Y, Zhang Z, Luo L, Guo Z, Li Z, Lin X, Bi L, Wang H*. Occurrence of High Levels of Cefiderocol Resistance in Carbapenem-Resistant Escherichia coli before Its Approval in China: a Report from China CRE-Network. Microbiol Spectr. 2022 Jun 29;10(3):e0267021.
Wang S#, Zhao C#, Yin Y, Chen F, Chen H, Wang H*. A Practical Approach for Predicting Antimicrobial Phenotype Resistance in Staphylococcus aureus Through Machine Learning Analysis of Genome Data. Front Microbiol. 2022 Mar 2;13:841289.
Zhang A, Wang X, Liang X, Zhou C, Wang Q, Zhang J, Wang H*. Performance Evaluation of Diagnostic Assays for Detection and Classification of Carbapenemase-Producing Organisms. Antibiotics (Basel). 2021 Nov 26;10(12):1457.Mislav Acman#, Ruobing Wang, Lucy van Dorp, Liam P. Shaw, Qi Wang, Nina Luhmann, Yuyao Yin, Shijun Sun, Hongbin Chen, Hui Wang, and Francois Balloux. Role of Mobile Genetic Elements in the Global Dissemination of the Carbapenem Resistance Gene Bla(NDM). Nature Communications 2022;13(1):1131.

Jiangang Zhang#, Jinru Xie#, Henan Li, Zhiren Wang, Yuyao Yin, Shuyi Wang, Hongbin Chen, Qi Wang, and Hui Wang*. Genomic and Phenotypic Evolution of Tigecycline-Resistant Acinetobacter Baumannii in Critically Ill Patients. Microbiology Spectrum 2022;10(1):e0159321.
Shijun Sun#, Qi Wang#, Longyang Jin#, Yifan Guo, Yuyao Yin, Ruobing Wang, Lei Bi, Renfei Zhang, Yungang Han, and Hui Wang*. Identification of Multiple Transfer Units and Novel Subtypes of TmexCD-ToprJ Gene Clusters in Clinical Carbapenem-Resistant Enterobacter Cloacae and Klebsiella Oxytoca. The Journal of Antimicrobial Chemotherapy 2022;77(3):625–32.
Lin-Lin Cao, Yi Han, Yuanxiao Wang, Lin Pei, Zhihong Yue, Li Qin, Boyu Liu, Jingwen Cui, Mei Jia, and Hui Wang. Metabolic Profiling Identified a Novel Biomarker Panel for Metabolic Syndrome-Positive Hepatocellular Cancer. Frontiers in Endocrinology 2022;12:816748.

Chen Z, Zhou C, Xu Y, Wen K, Song J, Bai S, Wu C, Huang W, Cai Q, Zhou K, Wang H, Wang Y, Feng X, Bai Y. An alternatingly amphiphilic, resistance-resistant antimicrobial oligoguanidine with dual mechanisms of action. Biomaterials. 2021 Aug;275:120858.

Zhiren Wang, Henan Li, Jiangang Zhang, Xiaojuan Wang, Yawei Zhang, and Hui Wang. Identification of a Novel Plasmid-Mediated Tigecycline Resistance-Related Gene, Tet(Y), in Acinetobacter Baumannii. The Journal of Antimicrobial Chemotherapy 2021;77(1):58–68.

Yawei Zhang, Xiaojuan Wang, Shifu Wang, Shijun Sun, Henan Li, Hongbin Chen, Qi Wang, and Hui Wang*. Emergence of Colistin Resistance in Carbapenem-Resistant Hypervirulent Klebsiella Pneumoniae Under the Pressure of Tigecycline. Frontiers in Microbiology 2021;12:756580.
Yifan Guo, Lijuan Li, Zhenzhong Li, Lingxiao Sun, and Hui Wang*. Tropheryma Whipplei Detection by Nanopore Sequencing in Patients With Interstitial Lung Disease. Frontiers in Microbiology 2021;12:760696.
Anru Zhang, Xiaojuan Wang, Xinyue Liang, Chaoe Zhou, Qi Wang, Jiangang Zhang, and Hui Wang*. Performance Evaluation of Diagnostic Assays for Detection and Classification of Carbapenemase-Producing Organisms. Antibiotics (Basel, Switzerland) 2021;10(12).
Yifan Guo#, Henan Li#, Hongbin Chen, Zhenzhong Li, Wenchao Ding, Jun Wang, Yuyao Yin, Longyang Jin, Shijun Sun, Chendi Jing, and Hui Wang*. Metagenomic Next-Generation Sequencing to Identify Pathogens and Cancer in Lung Biopsy Tissue. EBioMedicine 2021;73:103639.
Yawei Zhang, Xiaojuan Wang, Qi Wang, Hongbin Chen, Henan Li, Shuyi Wang, Ruobing Wang, and Hui Wang*. Emergence of Tigecycline Nonsusceptible and IMP-4 Carbapenemase-Producing K2-ST65 Hypervirulent Klebsiella Pneumoniae in China. Microbiology Spectrum 2021;9(2):e0130521.
Hongbin Chen#, Yuyao Yin#, Lucy van Dorp#*, Liam P. Shaw, Hua Gao, Mislav Acman, Jizhen Yuan, Fengning Chen, Shijun Sun, Xiaojuan Wang, Shuguang Li, Yawei Zhang, Rhys A. Farrer, Hui Wang*, and Francois Balloux*. Drivers of Methicillin-Resistant Staphylococcus Aureus (MRSA) Lineage Replacement in China. Genome Medicine 2021;13(1):171.
Zhiren Wang, Henan Li*, Jiangang Zhang, and Hui Wang*. 2021. Co-Occurrence of Bla(OXA-23) in the Chromosome and Plasmid: Increased Fitness in Carbapenem-Resistant Acinetobacter Baumannii. Antibiotics (Basel, Switzerland) 2021;10(10).
Henan Li, Jiangang Zhang, Zhiren Wang, Yuyao Yin, Hua Gao, Ruobing Wang, Longyang Jin, Qi Wang, Chunjiang Zhao, Zhanwei Wang, and Hui Wang*. Evolution of Acinetobacter Baumannii in Clinical Bacteremia Patients. Infection and Drug Resistance 2021;14:3553–62.
Chendi Jing#, Hongbin Chen#, Yong Liang#, Ying Zhong, Qi Wang*, Lifeng Li, Shijun Sun, Yifan Guo, Ruobing Wang, Zhi Jiang*, and Hui Wang*. Clinical Evaluation of an Improved Metagenomic Next-Generation Sequencing Test for the Diagnosis of Bloodstream Infections. Clinical Chemistry 2021;67(8):1133–43.
Yuanxiao Wang, Lin Pei, Zhihong Yue, Mei Jia, Hui Wang, and Lin-Lin Cao. The Potential of Serum Exosomal Hsa_circ_0028861 as the Novel Diagnostic Biomarker of HBV-Derived Hepatocellular Cancer. Frontiers in Genetics 2021;12:703205.
Chendi Jing, Chenghua Liu, Yu Liu, Ruli Feng, Run Cao, Zhangchun Guan, Bo Xuan … Hui Wang*. Antibodies Against Pseudomonas Aeruginosa Alkaline Protease Directly Enhance Disruption of Neutrophil Extracellular Traps Mediated by This Enzyme. Frontiers in Immunology 2021;12:654649.
Chaoe Zhou, Longyang Jin, Qi Wang, Xiaojuan Wang, Fengning Chen, Yue Gao, Chunjiang Zhao, Hongbin Chen, Bin Cao, and Hui Wang*. Bloodstream Infections Caused by Carbapenem-Resistant Enterobacterales: Risk Factors for Mortality, Antimicrobial Therapy and Treatment Outcomes from a Prospective Multicenter Study. Infection and Drug Resistance 2021;14:731–42.
Yuyao Yin, Chunjiang Zhao, Henan Li, Longyang Jin, Qi Wang, Ruobing Wang, Yawei Zhang, Jiangang Zhang, Hui Wang*, and CARES network. Clinical and Microbiological Characteristics of Adults with Hospital-Acquired Pneumonia: A 10-Year Prospective Observational Study in China. European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2021;40(4):683-690.
Longyang Jin, Ruobing Wang, Hua Gao, Qi Wang, Hui Wang*. Identification of a Novel Hybrid Plasmid Encoding KPC-2 and Virulence Factors in Klebsiella pneumoniae Sequence Type 11. Antimicrobial Agents and Chemotherapy 2021;65(6):e02435-20.
Bai S#, Wang J#, Yang K#, Zhou C, Xu Y, Song J, Gu Y, Chen Z, Wang M, Shoen C, Andrade B, Cynamon M, Zhou K, Wang H, Cai Q, Oldfield E, Zimmerman SC, Bai Y*, Feng X*. A polymeric approach toward resistance-resistant antimicrobial agent with dual-selective mechanisms of action. Sci Adv. 2021 Jan 27;7(5):eabc9917.

Longyang Jin, Chunjiang Zhao, Henan Li, Ruobing Wang, Qi Wang, Hui Wang*. Clinical Profile, Prognostic Factors, and Outcome Prediction in Hospitalized Patients With Bloodstream Infection: Results From a 10-Year Prospective Multicenter Study. Frontiers in Medicine 2021;8:629671.
Yawei Zhang, Chunjiang Zhao, Qi Wang … Hui Wang* Evaluation of the in vitro activity of new polymyxin B analogue SPR206 against clinical MDR, colistin-resistant and tigecycline-resistant Gram-negative bacilli. Journal of Antimicrobial Chemotherapy 2020; 75(9):2609-2615.
Yawei Zhang, Longyang Jin, Pengwen Ouyang … Hui Wang* Evolution of hypervirulence in carbapenem-resistant Klebsiella pneumoniae in China: a multicentre, molecular epidemiological analysis. Journal of Antimicrobial Chemotherapy 2020; 75(2):327-336.
Xiaojuan Wang, Chunjiang Zhao, Qi Wang … Hui Wang* In vitro activity of the novel β-lactamase inhibitor taniborbactam (VNRX-5133), in combination with cefepime or meropenem, against MDR Gram-negative bacterial isolates from China. Journal of Antimicrobial Chemotherapy 2020; 75(7):1850-1858.
Qi Wang, Zhanwei Wang, Feifei Zhang … Hui Wang* Long-term continuous antimicrobial resistance surveillance among nosocomial Gram-negative bacilli in China from 2010 to 2018 (CMSS). Infection and Drug Resistance 2020; 13:2617-2629.
Kaiying Wang#, Peihan Li#, Yanfeng Lin# … Peng Li*, Hui Wang*, Hongbin Song* Metagenomic diagnosis for a culture-negative sample from a patient with severe pneumonia by nanopore and next-generation sequencing. Frontiers in Cellular and Infection Microbiology 2020; 10:182.
Yudong Liu, Qi Wang, Chunjiang Zhao … Hui Wang* Prospective multi-center evaluation on risk factors, clinical characteristics and outcomes due to carbapenem resistance in Acinetobacter baumannii complex bacteraemia: experience from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) Network. Journal of Medical Microbiology 2020; 69(7):949-959.
Shijun Sun#, Hua Gao#, Yudong Liu# … Hui Wang* Co-existence of a novel plasmid-mediated efflux pump with colistin resistance gene mcr in one plasmid confers transferable multidrug resistance in Klebsiella pneumonia. Emerging Microbes & Infections 2020; 9(1):1102-1113.
Shuguang Li#, Liyan Lin#, Feifei Zhang … Hui Wang* A retrospective study on Xpert MTB/RIF for detection of tuberculosis in a teaching hospital in China. BMC Infectious Diseases 2020; 20(1):362.
Longyang Jin, Yudong Liu, Chendi Jing … Hui Wang* Neutrophil extracellular traps (NETs)-mediated killing of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) are impaired in patients with diabetes mellitus. Virulence 2020; 11(1):1122-1130.
Hua Gao#, Yudong Liu#, Ruobing Wang# … Hui Wang* The transferability and evolution of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings. EBioMedicine 2020; 51:102599.
Hongbin Chen, Yuyao Yin, Xiaohua Li … Hui Wang* Whole-genome analysis of livestock-associated methicillin-resistant Staphylococcus aureus sequence type 398 strains isolated from patients with bacteremia in China. Journal of Infectious Diseases 2020; 221(Supplement_2):S220-S228.
Yuyao Yin, Hongbin Chen, Shuguang Li … Hui Wang* Daptomycin resistance in methicillin-resistant Staphylococcus aureus is conferred by IS256 insertion in the promoter of mprF along with mutations in mprF and walK. International Journal of Antimicrobial Agents 2019; 54(6):673-680.
Xiaojuan Wang#, Qi Wang#, Bin Cao … Hui Wang* Retrospective observational study from a Chinese network of the impact of combination therapy versus monotherapy on mortality from carbapenem-resistant Enterobacteriaceae bacteremia. Antimicrobial Agents and Chemotherapy 2019; 63(1):e01511-18.
Lucy van Dorp#*, Qi Wang#, Liam P Shaw … Francois Balloux*, Hui Wang* Rapid phenotypic evolution in multidrug-resistant Klebsiella pneumoniae hospital outbreak strains. Microbial Genomics 2019; 5(4):e000263.
Yi Shi#, Yi Huang#, Tian-Tuo Zhang#, Bin Cao#, Hui Wang# … Jie-Ming Qu* Chinese guidelines for the diagnosis and treatment of hospital-acquired pneumonia and ventilator-associated pneumonia in adults (2018 Edition). Journal of Thoracic Disease 2019; 11(6):2581-2616.
Hongbin Chen#, Xiaojuan Wang#, Yuyao Yin … Hui Wang* Molecular characteristics of oxazolidinone resistance in enterococci from a multicenter study in China. BMC Microbiology 2019; 19(1):162.
Yawei Zhang#, Qi Wang#, Yuyao Yin … Hui Wang* Epidemiology of carbapenem-resistant Enterobacteriaceae infections: report from the China CRE Network. Antimicrobial Agents and Chemotherapy 2018; 62(2):e01882-17.
Zhao X#, Jia Y#, Li J, Dong R, Zhang J, Ma C, Wang H, Rui Y*, Jiang X*. Indole Derivative-Capped Gold Nanoparticles as an Effective Bactericide in Vivo. ACS Appl Mater Interfaces. 2018 Sep 5;10(35):29398-29406.

Jiangang Zhang, Chunjiang Zhao, Hongbin Chen … Hui Wang* A multicenter epidemiology study on the risk factors and clinical outcomes of nosocomial intra-abdominal infections in China: results from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) 2007-2016. Infection and Drug Resistance 2018; 11:2311-2319.
Zhi-hong Yue#, Chang-sheng Xia#, Hui Wang* Performance evaluation of the mindray anti-HCV assay for the detection of hepatitis C virus infection. Journal of Clinical Laboratory Analysis 2018; 32(9):e22600.
Chang-Sheng Xia*, Zhi-Hong Yue*, Hui Wang* Evaluation of three automated Treponema pallidum antibody assays for syphilis screening. Journal of Infection and Chemotherapy 2018; 24(11):887-891.
Xiaojuan Wang#, Jian Bing#, Qiushi Zheng# … Hui Wang*, Guanghua Huang* The first isolate of Candida auris in China: clinical and biological aspects. Emerging Microbes & Infections 2018; 7(1):93.

Ruobing Wang#, Lucy van Dorp#, Liam P Shaw# … Hui Wang*, Francois Balloux* The global distribution and spread of the mobilized colistin resistance gene mcr-1. Nature Communications 2018; 9(1):1179.
Ruobing Wang#, Yuqing Liu#, Qing Zhang … Hui Wang* The prevalence of colistin resistance in Escherichia coli and Klebsiella pneumoniae isolated from food animals in China: coexistence of mcr-1 and blaNDM with low fitness cost. International Journal of Antimicrobial Agents 2018; 51(5):739-744.
Qi Wang#, Xiaojuan Wang#, Juan Wang … Hui Wang* Phenotypic and genotypic characterization of carbapenem-resistant Enterobacteriaceae: data from a longitudinal large-scale CRE study in China (2012-2016). Clinical Infectious Diseases 2018; 67(suppl_2):S196-S205.
Chen Liu*, Dongwei Wang, Ying Song … Hui Wang* Increased circulating CD4+ CXCR5+ FoxP3+ follicular regulatory T cells correlated with severity of systemic lupus erythematosus patients. International Immunopharmacology 2018; 56:261-268.
Shuguang Li, Shijun Sun, Chentao Yang … Hui Wang* The changing pattern of population structure of Staphylococcus aureus from bacteremia in China from 2013 to 2016: ST239-030-MRSA replaced by ST59-t437. Frontiers in Microbiology 2018; 9:332.
Henan Li, Hua Gao, Han Meng … Hui Wang* Detection of pulmonary infectious pathogens from lung biopsy tissues by metagenomic next-generation sequencing. Frontiers in Cellular and Infection Microbiology 2018; 8:205.
Longyang Jin#, Ruobing Wang#, Xiaojuan Wang … Hui Wang* Emergence of mcr-1 and carbapenemase genes in hospital sewage water in Beijing, China. Journal of Antimicrobial Chemotherapy 2018; 73(1):84-87.
Chunmei Jin#, Jiangang Zhang#, Qi Wang … Hui Wang* Molecular characterization of carbapenem-resistant Enterobacter cloacae in 11 Chinese cities. Frontiers in Microbiology 2018; 9:1597.
Hongbin Chen, Qi Wang, Yuyao Yin … Deng-Ke Niu*, Hui Wang* Genotypic variations between wild-type and small colony variant of Staphylococcus aureus in prosthetic valve infectious endocarditis: a comparative genomic and transcriptomic analysis. International Journal of Antimicrobial Agents 2018, 51(4):655-658.
Chunjiang Zhao#, Zongbo Li#, Feifei Zhang … Hui Wang* Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolates from 17 Chinese cities from 2011 to 2016. BMC Infectious Diseases 2017; 17(1):804.
Yawei Zhang#, Kang Liao#, Hua Gao# … Hui Wang* Decreased fitness and virulence in ST10 Escherichia coli harboring blaNDM-5 and mcr-1 against a ST4981 strain with blaNDM-5. Frontiers in Cellular and Infection Microbiology 2017; 7:242.
Xiaojuan Wang#, Yuqing Liu#, Xiaomei Qi … Hui Wang* Molecular epidemiology of colistin-resistant Enterobacteriaceae in inpatient and avian isolates from China: high prevalence of mcr-negative Klebsiella pneumonia. International Journal of Antimicrobial Agents 2017; 50(4):536-541.
Ruobing Wang, Xuebin Li, Qi Wang … Hui Wang* Microbiological characteristics and clinical features of cardiac implantable electronic device infections at a tertiary hospital in China. Frontiers in Microbiology 2017; 8:360.
Chen Liu*, Lei Zhao, Jingzhong Zhao … Hui Wang* Decreased ADAMTS-13 level is related to inflammation factors and risk stratification of acute lymphoblastic leukemia patients. Medicine 2017; 96(7):e6136.
Chen Liu, Lei Zhao, Jingzhong Zhao … Hui Wang* Reduced ADAMTS-13 level negatively correlates with inflammation factors in plasma of acute myeloid leukemia patients. Leukemia Research 2017; 53:57-64.
Shuguang Li#, Yuyao Yin#, Hongbin Chen … Hui Wang* Fitness cost of daptomycin-resistant Staphylococcus aureus obtained from in vitro daptomycin selection pressure. Frontiers in Microbiology 2017; 8:2199.
Henan Li, Qi Wang, Ruobing Wang … Hui Wang* Global regulator SoxR is a negative regulator of efflux pump gene expression and affects antibiotic resistance and fitness in Acinetobacter baumannii. Medicine 2017; 96(24):e7188.
Yawei Zhang, Chunjiang Zhao, Qi Wang … Hui Wang* High prevalence of hypervirulent Klebsiella pneumoniae infection in China: geographic distribution, clinical characteristics, and antimicrobial resistance. Antimicrobial Agents and Chemotherapy 2016; 60(10):6115-20.
Yawei Zhang, Feifei Zhang, Hui Wang* … Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respiratory tract infections in China: results from the CARTIPS Antimicrobial Surveillance Program. Journal of Global Antimicrobial Resistance 2016; 5:36-41.
Qi Wang, Yawei Zhang, X Yao … Hui Wang* Risk factors and clinical outcomes for carbapenem-resistant Enterobacteriaceae nosocomial infections. European Journal of Clinical Microbiology & Infectious Diseases 2016; 35(10):1679-89.
Shuguang Li#, Yu Gao#, Chunjiang Zhao … Hui Wang* In vitro activities of tedizolid compared with other antibiotics against Gram-positive pathogens associated with hospital-acquired pneumonia, skin and soft tissue infection and bloodstream infection collected from 26 hospitals in China. Journal of Medical Microbiology 2016; 65(10):1215-1224.
Hongbin Chen#, Zhujia Xiong#, Kuoyue Liu# … Hui Wang* Transcriptional profiling of the two-component regulatory system VraSR in Staphylococcus aureus with low-level vancomycin resistance. International Journal of Antimicrobial Agents 2016; 47(5):362-7.

Sun L, Mi S, Fan C, Guo Y, Wang H*. Anchovy-like fluid drained from a huge liver abscess: A diagnostic challenge. Travel Med Infect Dis. 2024 Mar-Apr;58:102705
Zheng J, Chen S, Song M, Liu B, Ma S, Wang S, Wang Q, Ding Q, Xia Q, Zhu K, Wang H*. Discovery of adjuvants with antibacterial potentiation activity against carbapenemase-producing Enterobacterales based on in silico virtual screening. Int J Antimicrob Agents. 2024 Feb;63(2):107076.
Chen F, Yin Y, Chen H, Wang R, Wang S, Wang H*. Global genetic diversity and Asian clades evolution: a phylogeographic study of Staphylococcus aureus sequence type 5. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0117523.
Wang Q, Wang R, Wang S, Zhang A, Duan Q, Sun S, Jin L, Wang X, Zhang Y, Wang C, Kang H, Zhang Z, Liao K, Guo Y, Jin L, Liu Z, Yang C, Wang H*; China Carbapenem-Resistant Enterobacterales (CRE) Network. Expansion and transmission dynamics of high risk carbapenem-resistant Klebsiella pneumoniae subclones in China: An epidemiological, spatial, genomic analysis. Drug Resist Updat. 2024 Mar 29;74:101083.
Sun S, Cai M, Wang Q, Wang S, Zhang L, Wang H*. Emergency of the plasmid co-carrying bla_KPC-2 and bla_NDM-1 genes in carbapenem-resistant hypervirulent Klebsiella pneumoniae. J Glob Antimicrob Resist. 2024 Mar;36:26-32.
Wang R, Zhang A, Sun S, Yin G, Wu X, Ding Q, Wang Q, Chen F, Wang S, van Dorp L, Zhang Y, Jin L, Wang X, Balloux F, Wang H*. Increase in antioxidant capacity associated with the successful subclone of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11-KL64. Nat Commun. 2024 Jan 2;15(1):67.
Chen H, Zheng Y, Zhang X, Liu S, Yin Y, Guo Y, Wang X, Zhang Y, Zhao C, Gai W, Wang H*. Clinical evaluation of cell-free and cellular metagenomic next-generation sequencing of infected body fluids. J Adv Res. 2024 Jan;55:119-129.
Liu S, Chen H, Xu F, Chen F, Yin Y, Zhang X, Tu S, Wang H*. Unravelling staphylococcal small-colony variants in cardiac implantable electronic device infections: clinical characteristics, management, and genomic insights. Front Cell Infect Microbiol. 2024 Jan 8;13:1321626.
Gao Y, Li H, Zhao C, Li S, Yin G, Wang H*. Machine learning and feature extraction for rapid antimicrobial resistance prediction of Acinetobacter baumannii from whole-genome sequencing data. Front Microbiol. 2024 Jan 11;14:1320312.
Yin G, Guo Y, Ding Q, Ma S, Chen F, Wang Q, Chen H, Wang H*. Klebsiella quasipneumoniae in intestine damages bile acid metabolism in hematopoietic stem cell transplantation patients with bloodstream infection. J Transl Med. 2023 Mar 29;21(1):230.
Chen H#, Zheng Y#, Zhang X, Liu S, Yin Y, Guo Y, Wang X, Zhang Y, Zhao C, Gai W*, Wang H*. Clinical evaluation of cell-free and cellular metagenomic next-generation sequencing of infected body fluids. J Adv Res. 2023 Mar 6:S2090-1232(23)00068-1.
Liu S#, Chen H#*, Chen J, Wang T, Tu S, Zhang X, Wang Q, Yin Y, Zhang Y, Wang X, Zhao C, Wang H*. Transcriptome and Proteome of Methicillin-Resistant Staphylococcus aureus Small-Colony Variants Reveal Changed Metabolism and Increased Immune Evasion. Microbiol Spectr. 2023 Feb 14:e0189822.
Wang H*. Current and Future Landscape of the Antimicrobial Resistance of Nosocomial Infections in China. China CDC Wkly. 2022 Dec 9;4(49):1101-1104.
Wang Z, Fan X, Wang S, Li S, Gao Y, Wang H, Li H*. Emergence of Colistin-Resistant Acinetobacter junii in China. Antibiotics (Basel). 2022 Nov 24;11(12):1693.
Chen F, Yin Y, Chen H, Jin L, Li S, Wang R, Wang S, Wang Q, Sun S, Wang H*. Phenotypic and Genomic Comparison of Staphylococcus aureus Highlight Virulence and Host Adaptation Favoring the Success of Epidemic Clones. mSystems. 2022 Dec 20;7(6):e0083122.
Zhang P#, Wang Q#, Zhou C, Zhang F, Gao X, Tenover FC, Tang YW, Wang H*. A Pooling Strategy for Detecting Carbapenem Resistance Genes by the Xpert Carba-R Test in Rectal Swab Specimens. J Clin Microbiol. 2022 Dec 21;60(12):e0118122.
Duan Q#, Wang Q#, Sun S, Cui Q, Ding Q, Wang R, Wang H*. ST11 Carbapenem-Resistant Klebsiella pneumoniae Clone Harboring blaNDM Replaced a blaKPC Clone in a Tertiary Hospital in China. Antibiotics (Basel). 2022 Oct 7;11(10):1373.
Lo SW*, Mellor K, Cohen R, Alonso AR, Belman S, Kumar N, Hawkins PA, Gladstone RA, von Gottberg A, Veeraraghavan B, Ravikumar KL, Kandasamy R, Pollard SAJ, Saha SK, Bigogo G, Antonio M, Kwambana-Adams B, Mirza S, Shakoor S, Nisar I, Cornick JE, Lehmann D, Ford RL, Sigauque B, Turner P, Moïsi J, Obaro SK, Dagan R, Diawara I, Skoczyńska A, Wang H, Carter PE, Klugman KP, Rodgers G, Breiman RF, McGee L, Bentley SD, Muñoz-Almagro C, Varon E; Global Pneumococcal Sequencing Consortium. Emergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole-genome sequencing study. Lancet Microbe. 2022 Oct;3(10):e735-e743.
Jia Y, Zhang J, Zhao Y, Dong R, Wang H, Jiang X*. Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria. Chem Commun (Camb). 2022 Sep 20;58(75):10544-10547.
Wang S#, Ding Q#, Zhang Y, Zhang A, Wang Q, Wang R, Wang X, Jin L, Ma S, Wang H*. Evolution of Virulence, Fitness, and Carbapenem Resistance Transmission in ST23 Hypervirulent Klebsiella pneumoniae with the Capsular Polysaccharide Synthesis Gene wcaJ Inserted via Insertion Sequence Elements. Microbiol Spectr. 2022 Dec 21;10(6):e0240022.
Zhao C, Yang S, Zhang F, Wang Z, Zhang Y, Wang X, Li H, Chen H, Wang H*. Antimicrobial Resistance Trends of the Most Common Causative Pathogens Associated with Community-acquired Respiratory Infections in China: 2009-2018. Infect Drug Resist. 2022 Aug 31;15:5069-5083.
Chen H, Li M, Tu S, Zhang X, Wang X, Zhang Y, Zhao C, Guo Y, Wang H*. Metagenomic data from cerebrospinal fluid permits tracing the origin and spread of Neisseria meningitidis CC4821 in China. Commun Biol. 2022 Aug 18;5(1):839.
Cao LL, Han Y, Pei L, Yue ZH, Liu BY, Cui JW, Jia M, Wang H*. A Serum Metabolite Classifier for the Early Detection of Type 2 Diabetes Mellitus-Positive Hepatocellular Cancer. Metabolites. 2022 Jul 1;12(7):610.
Gao Y, Li H, Chen H, Zhang J, Wang R, Wang Z, Wang H*. Origin, Phylogeny, and Transmission of the Epidemic Clone ST208 of Carbapenem-Resistant Acinetobacter baumannii on a Global Scale. Microbiol Spectr. 2022 Jun 29;10(3):e0260421.
Wang Q, Jin L, Sun S, Yin Y, Wang R, Chen F, Wang X, Zhang Y, Hou J, Zhang Y, Zhang Z, Luo L, Guo Z, Li Z, Lin X, Bi L, Wang H*. Occurrence of High Levels of Cefiderocol Resistance in Carbapenem-Resistant Escherichia coli before Its Approval in China: a Report from China CRE-Network. Microbiol Spectr. 2022 Jun 29;10(3):e0267021.
Wang S#, Zhao C#, Yin Y, Chen F, Chen H, Wang H*. A Practical Approach for Predicting Antimicrobial Phenotype Resistance in Staphylococcus aureus Through Machine Learning Analysis of Genome Data. Front Microbiol. 2022 Mar 2;13:841289.
Zhang A, Wang X, Liang X, Zhou C, Wang Q, Zhang J, Wang H*. Performance Evaluation of Diagnostic Assays for Detection and Classification of Carbapenemase-Producing Organisms. Antibiotics (Basel). 2021 Nov 26;10(12):1457.Mislav Acman#, Ruobing Wang, Lucy van Dorp, Liam P. Shaw, Qi Wang, Nina Luhmann, Yuyao Yin, Shijun Sun, Hongbin Chen, Hui Wang, and Francois Balloux. Role of Mobile Genetic Elements in the Global Dissemination of the Carbapenem Resistance Gene Bla(NDM). Nature Communications 2022;13(1):1131.

Jiangang Zhang#, Jinru Xie#, Henan Li, Zhiren Wang, Yuyao Yin, Shuyi Wang, Hongbin Chen, Qi Wang, and Hui Wang*. Genomic and Phenotypic Evolution of Tigecycline-Resistant Acinetobacter Baumannii in Critically Ill Patients. Microbiology Spectrum 2022;10(1):e0159321.
Shijun Sun#, Qi Wang#, Longyang Jin#, Yifan Guo, Yuyao Yin, Ruobing Wang, Lei Bi, Renfei Zhang, Yungang Han, and Hui Wang*. Identification of Multiple Transfer Units and Novel Subtypes of TmexCD-ToprJ Gene Clusters in Clinical Carbapenem-Resistant Enterobacter Cloacae and Klebsiella Oxytoca. The Journal of Antimicrobial Chemotherapy 2022;77(3):625–32.
Lin-Lin Cao, Yi Han, Yuanxiao Wang, Lin Pei, Zhihong Yue, Li Qin, Boyu Liu, Jingwen Cui, Mei Jia, and Hui Wang. Metabolic Profiling Identified a Novel Biomarker Panel for Metabolic Syndrome-Positive Hepatocellular Cancer. Frontiers in Endocrinology 2022;12:816748.

Chen Z, Zhou C, Xu Y, Wen K, Song J, Bai S, Wu C, Huang W, Cai Q, Zhou K, Wang H, Wang Y, Feng X, Bai Y. An alternatingly amphiphilic, resistance-resistant antimicrobial oligoguanidine with dual mechanisms of action. Biomaterials. 2021 Aug;275:120858.

Zhiren Wang, Henan Li, Jiangang Zhang, Xiaojuan Wang, Yawei Zhang, and Hui Wang. Identification of a Novel Plasmid-Mediated Tigecycline Resistance-Related Gene, Tet(Y), in Acinetobacter Baumannii. The Journal of Antimicrobial Chemotherapy 2021;77(1):58–68.

Yawei Zhang, Xiaojuan Wang, Shifu Wang, Shijun Sun, Henan Li, Hongbin Chen, Qi Wang, and Hui Wang*. Emergence of Colistin Resistance in Carbapenem-Resistant Hypervirulent Klebsiella Pneumoniae Under the Pressure of Tigecycline. Frontiers in Microbiology 2021;12:756580.
Yifan Guo, Lijuan Li, Zhenzhong Li, Lingxiao Sun, and Hui Wang*. Tropheryma Whipplei Detection by Nanopore Sequencing in Patients With Interstitial Lung Disease. Frontiers in Microbiology 2021;12:760696.
Anru Zhang, Xiaojuan Wang, Xinyue Liang, Chaoe Zhou, Qi Wang, Jiangang Zhang, and Hui Wang*. Performance Evaluation of Diagnostic Assays for Detection and Classification of Carbapenemase-Producing Organisms. Antibiotics (Basel, Switzerland) 2021;10(12).
Yifan Guo#, Henan Li#, Hongbin Chen, Zhenzhong Li, Wenchao Ding, Jun Wang, Yuyao Yin, Longyang Jin, Shijun Sun, Chendi Jing, and Hui Wang*. Metagenomic Next-Generation Sequencing to Identify Pathogens and Cancer in Lung Biopsy Tissue. EBioMedicine 2021;73:103639.
Yawei Zhang, Xiaojuan Wang, Qi Wang, Hongbin Chen, Henan Li, Shuyi Wang, Ruobing Wang, and Hui Wang*. Emergence of Tigecycline Nonsusceptible and IMP-4 Carbapenemase-Producing K2-ST65 Hypervirulent Klebsiella Pneumoniae in China. Microbiology Spectrum 2021;9(2):e0130521.
Hongbin Chen#, Yuyao Yin#, Lucy van Dorp#*, Liam P. Shaw, Hua Gao, Mislav Acman, Jizhen Yuan, Fengning Chen, Shijun Sun, Xiaojuan Wang, Shuguang Li, Yawei Zhang, Rhys A. Farrer, Hui Wang*, and Francois Balloux*. Drivers of Methicillin-Resistant Staphylococcus Aureus (MRSA) Lineage Replacement in China. Genome Medicine 2021;13(1):171.
Zhiren Wang, Henan Li*, Jiangang Zhang, and Hui Wang*. 2021. Co-Occurrence of Bla(OXA-23) in the Chromosome and Plasmid: Increased Fitness in Carbapenem-Resistant Acinetobacter Baumannii. Antibiotics (Basel, Switzerland) 2021;10(10).
Henan Li, Jiangang Zhang, Zhiren Wang, Yuyao Yin, Hua Gao, Ruobing Wang, Longyang Jin, Qi Wang, Chunjiang Zhao, Zhanwei Wang, and Hui Wang*. Evolution of Acinetobacter Baumannii in Clinical Bacteremia Patients. Infection and Drug Resistance 2021;14:3553–62.
Chendi Jing#, Hongbin Chen#, Yong Liang#, Ying Zhong, Qi Wang*, Lifeng Li, Shijun Sun, Yifan Guo, Ruobing Wang, Zhi Jiang*, and Hui Wang*. Clinical Evaluation of an Improved Metagenomic Next-Generation Sequencing Test for the Diagnosis of Bloodstream Infections. Clinical Chemistry 2021;67(8):1133–43.
Yuanxiao Wang, Lin Pei, Zhihong Yue, Mei Jia, Hui Wang, and Lin-Lin Cao. The Potential of Serum Exosomal Hsa_circ_0028861 as the Novel Diagnostic Biomarker of HBV-Derived Hepatocellular Cancer. Frontiers in Genetics 2021;12:703205.
Chendi Jing, Chenghua Liu, Yu Liu, Ruli Feng, Run Cao, Zhangchun Guan, Bo Xuan … Hui Wang*. Antibodies Against Pseudomonas Aeruginosa Alkaline Protease Directly Enhance Disruption of Neutrophil Extracellular Traps Mediated by This Enzyme. Frontiers in Immunology 2021;12:654649.
Chaoe Zhou, Longyang Jin, Qi Wang, Xiaojuan Wang, Fengning Chen, Yue Gao, Chunjiang Zhao, Hongbin Chen, Bin Cao, and Hui Wang*. Bloodstream Infections Caused by Carbapenem-Resistant Enterobacterales: Risk Factors for Mortality, Antimicrobial Therapy and Treatment Outcomes from a Prospective Multicenter Study. Infection and Drug Resistance 2021;14:731–42.
Yuyao Yin, Chunjiang Zhao, Henan Li, Longyang Jin, Qi Wang, Ruobing Wang, Yawei Zhang, Jiangang Zhang, Hui Wang*, and CARES network. Clinical and Microbiological Characteristics of Adults with Hospital-Acquired Pneumonia: A 10-Year Prospective Observational Study in China. European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2021;40(4):683-690.
Longyang Jin, Ruobing Wang, Hua Gao, Qi Wang, Hui Wang*. Identification of a Novel Hybrid Plasmid Encoding KPC-2 and Virulence Factors in Klebsiella pneumoniae Sequence Type 11. Antimicrobial Agents and Chemotherapy 2021;65(6):e02435-20.
Bai S#, Wang J#, Yang K#, Zhou C, Xu Y, Song J, Gu Y, Chen Z, Wang M, Shoen C, Andrade B, Cynamon M, Zhou K, Wang H, Cai Q, Oldfield E, Zimmerman SC, Bai Y*, Feng X*. A polymeric approach toward resistance-resistant antimicrobial agent with dual-selective mechanisms of action. Sci Adv. 2021 Jan 27;7(5):eabc9917.

Longyang Jin, Chunjiang Zhao, Henan Li, Ruobing Wang, Qi Wang, Hui Wang*. Clinical Profile, Prognostic Factors, and Outcome Prediction in Hospitalized Patients With Bloodstream Infection: Results From a 10-Year Prospective Multicenter Study. Frontiers in Medicine 2021;8:629671.
Yawei Zhang, Chunjiang Zhao, Qi Wang … Hui Wang* Evaluation of the in vitro activity of new polymyxin B analogue SPR206 against clinical MDR, colistin-resistant and tigecycline-resistant Gram-negative bacilli. Journal of Antimicrobial Chemotherapy 2020; 75(9):2609-2615.
Yawei Zhang, Longyang Jin, Pengwen Ouyang … Hui Wang* Evolution of hypervirulence in carbapenem-resistant Klebsiella pneumoniae in China: a multicentre, molecular epidemiological analysis. Journal of Antimicrobial Chemotherapy 2020; 75(2):327-336.
Xiaojuan Wang, Chunjiang Zhao, Qi Wang … Hui Wang* In vitro activity of the novel β-lactamase inhibitor taniborbactam (VNRX-5133), in combination with cefepime or meropenem, against MDR Gram-negative bacterial isolates from China. Journal of Antimicrobial Chemotherapy 2020; 75(7):1850-1858.
Qi Wang, Zhanwei Wang, Feifei Zhang … Hui Wang* Long-term continuous antimicrobial resistance surveillance among nosocomial Gram-negative bacilli in China from 2010 to 2018 (CMSS). Infection and Drug Resistance 2020; 13:2617-2629.
Kaiying Wang#, Peihan Li#, Yanfeng Lin# … Peng Li*, Hui Wang*, Hongbin Song* Metagenomic diagnosis for a culture-negative sample from a patient with severe pneumonia by nanopore and next-generation sequencing. Frontiers in Cellular and Infection Microbiology 2020; 10:182.
Yudong Liu, Qi Wang, Chunjiang Zhao … Hui Wang* Prospective multi-center evaluation on risk factors, clinical characteristics and outcomes due to carbapenem resistance in Acinetobacter baumannii complex bacteraemia: experience from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) Network. Journal of Medical Microbiology 2020; 69(7):949-959.
Shijun Sun#, Hua Gao#, Yudong Liu# … Hui Wang* Co-existence of a novel plasmid-mediated efflux pump with colistin resistance gene mcr in one plasmid confers transferable multidrug resistance in Klebsiella pneumonia. Emerging Microbes & Infections 2020; 9(1):1102-1113.
Shuguang Li#, Liyan Lin#, Feifei Zhang … Hui Wang* A retrospective study on Xpert MTB/RIF for detection of tuberculosis in a teaching hospital in China. BMC Infectious Diseases 2020; 20(1):362.
Longyang Jin, Yudong Liu, Chendi Jing … Hui Wang* Neutrophil extracellular traps (NETs)-mediated killing of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) are impaired in patients with diabetes mellitus. Virulence 2020; 11(1):1122-1130.
Hua Gao#, Yudong Liu#, Ruobing Wang# … Hui Wang* The transferability and evolution of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings. EBioMedicine 2020; 51:102599.
Hongbin Chen, Yuyao Yin, Xiaohua Li … Hui Wang* Whole-genome analysis of livestock-associated methicillin-resistant Staphylococcus aureus sequence type 398 strains isolated from patients with bacteremia in China. Journal of Infectious Diseases 2020; 221(Supplement_2):S220-S228.
Yuyao Yin, Hongbin Chen, Shuguang Li … Hui Wang* Daptomycin resistance in methicillin-resistant Staphylococcus aureus is conferred by IS256 insertion in the promoter of mprF along with mutations in mprF and walK. International Journal of Antimicrobial Agents 2019; 54(6):673-680.
Xiaojuan Wang#, Qi Wang#, Bin Cao … Hui Wang* Retrospective observational study from a Chinese network of the impact of combination therapy versus monotherapy on mortality from carbapenem-resistant Enterobacteriaceae bacteremia. Antimicrobial Agents and Chemotherapy 2019; 63(1):e01511-18.
Lucy van Dorp#*, Qi Wang#, Liam P Shaw … Francois Balloux*, Hui Wang* Rapid phenotypic evolution in multidrug-resistant Klebsiella pneumoniae hospital outbreak strains. Microbial Genomics 2019; 5(4):e000263.
Yi Shi#, Yi Huang#, Tian-Tuo Zhang#, Bin Cao#, Hui Wang# … Jie-Ming Qu* Chinese guidelines for the diagnosis and treatment of hospital-acquired pneumonia and ventilator-associated pneumonia in adults (2018 Edition). Journal of Thoracic Disease 2019; 11(6):2581-2616.
Hongbin Chen#, Xiaojuan Wang#, Yuyao Yin … Hui Wang* Molecular characteristics of oxazolidinone resistance in enterococci from a multicenter study in China. BMC Microbiology 2019; 19(1):162.
Yawei Zhang#, Qi Wang#, Yuyao Yin … Hui Wang* Epidemiology of carbapenem-resistant Enterobacteriaceae infections: report from the China CRE Network. Antimicrobial Agents and Chemotherapy 2018; 62(2):e01882-17.
Zhao X#, Jia Y#, Li J, Dong R, Zhang J, Ma C, Wang H, Rui Y*, Jiang X*. Indole Derivative-Capped Gold Nanoparticles as an Effective Bactericide in Vivo. ACS Appl Mater Interfaces. 2018 Sep 5;10(35):29398-29406.

Jiangang Zhang, Chunjiang Zhao, Hongbin Chen … Hui Wang* A multicenter epidemiology study on the risk factors and clinical outcomes of nosocomial intra-abdominal infections in China: results from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) 2007-2016. Infection and Drug Resistance 2018; 11:2311-2319.
Zhi-hong Yue#, Chang-sheng Xia#, Hui Wang* Performance evaluation of the mindray anti-HCV assay for the detection of hepatitis C virus infection. Journal of Clinical Laboratory Analysis 2018; 32(9):e22600.
Chang-Sheng Xia*, Zhi-Hong Yue*, Hui Wang* Evaluation of three automated Treponema pallidum antibody assays for syphilis screening. Journal of Infection and Chemotherapy 2018; 24(11):887-891.
Xiaojuan Wang#, Jian Bing#, Qiushi Zheng# … Hui Wang*, Guanghua Huang* The first isolate of Candida auris in China: clinical and biological aspects. Emerging Microbes & Infections 2018; 7(1):93.

Ruobing Wang#, Lucy van Dorp#, Liam P Shaw# … Hui Wang*, Francois Balloux* The global distribution and spread of the mobilized colistin resistance gene mcr-1. Nature Communications 2018; 9(1):1179.
Ruobing Wang#, Yuqing Liu#, Qing Zhang … Hui Wang* The prevalence of colistin resistance in Escherichia coli and Klebsiella pneumoniae isolated from food animals in China: coexistence of mcr-1 and blaNDM with low fitness cost. International Journal of Antimicrobial Agents 2018; 51(5):739-744.
Qi Wang#, Xiaojuan Wang#, Juan Wang … Hui Wang* Phenotypic and genotypic characterization of carbapenem-resistant Enterobacteriaceae: data from a longitudinal large-scale CRE study in China (2012-2016). Clinical Infectious Diseases 2018; 67(suppl_2):S196-S205.
Chen Liu*, Dongwei Wang, Ying Song … Hui Wang* Increased circulating CD4+ CXCR5+ FoxP3+ follicular regulatory T cells correlated with severity of systemic lupus erythematosus patients. International Immunopharmacology 2018; 56:261-268.
Shuguang Li, Shijun Sun, Chentao Yang … Hui Wang* The changing pattern of population structure of Staphylococcus aureus from bacteremia in China from 2013 to 2016: ST239-030-MRSA replaced by ST59-t437. Frontiers in Microbiology 2018; 9:332.
Henan Li, Hua Gao, Han Meng … Hui Wang* Detection of pulmonary infectious pathogens from lung biopsy tissues by metagenomic next-generation sequencing. Frontiers in Cellular and Infection Microbiology 2018; 8:205.
Longyang Jin#, Ruobing Wang#, Xiaojuan Wang … Hui Wang* Emergence of mcr-1 and carbapenemase genes in hospital sewage water in Beijing, China. Journal of Antimicrobial Chemotherapy 2018; 73(1):84-87.
Chunmei Jin#, Jiangang Zhang#, Qi Wang … Hui Wang* Molecular characterization of carbapenem-resistant Enterobacter cloacae in 11 Chinese cities. Frontiers in Microbiology 2018; 9:1597.
Hongbin Chen, Qi Wang, Yuyao Yin … Deng-Ke Niu*, Hui Wang* Genotypic variations between wild-type and small colony variant of Staphylococcus aureus in prosthetic valve infectious endocarditis: a comparative genomic and transcriptomic analysis. International Journal of Antimicrobial Agents 2018, 51(4):655-658.
Chunjiang Zhao#, Zongbo Li#, Feifei Zhang … Hui Wang* Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolates from 17 Chinese cities from 2011 to 2016. BMC Infectious Diseases 2017; 17(1):804.
Yawei Zhang#, Kang Liao#, Hua Gao# … Hui Wang* Decreased fitness and virulence in ST10 Escherichia coli harboring blaNDM-5 and mcr-1 against a ST4981 strain with blaNDM-5. Frontiers in Cellular and Infection Microbiology 2017; 7:242.
Xiaojuan Wang#, Yuqing Liu#, Xiaomei Qi … Hui Wang* Molecular epidemiology of colistin-resistant Enterobacteriaceae in inpatient and avian isolates from China: high prevalence of mcr-negative Klebsiella pneumonia. International Journal of Antimicrobial Agents 2017; 50(4):536-541.
Ruobing Wang, Xuebin Li, Qi Wang … Hui Wang* Microbiological characteristics and clinical features of cardiac implantable electronic device infections at a tertiary hospital in China. Frontiers in Microbiology 2017; 8:360.
Chen Liu*, Lei Zhao, Jingzhong Zhao … Hui Wang* Decreased ADAMTS-13 level is related to inflammation factors and risk stratification of acute lymphoblastic leukemia patients. Medicine 2017; 96(7):e6136.
Chen Liu, Lei Zhao, Jingzhong Zhao … Hui Wang* Reduced ADAMTS-13 level negatively correlates with inflammation factors in plasma of acute myeloid leukemia patients. Leukemia Research 2017; 53:57-64.
Shuguang Li#, Yuyao Yin#, Hongbin Chen … Hui Wang* Fitness cost of daptomycin-resistant Staphylococcus aureus obtained from in vitro daptomycin selection pressure. Frontiers in Microbiology 2017; 8:2199.
Henan Li, Qi Wang, Ruobing Wang … Hui Wang* Global regulator SoxR is a negative regulator of efflux pump gene expression and affects antibiotic resistance and fitness in Acinetobacter baumannii. Medicine 2017; 96(24):e7188.
Yawei Zhang, Chunjiang Zhao, Qi Wang … Hui Wang* High prevalence of hypervirulent Klebsiella pneumoniae infection in China: geographic distribution, clinical characteristics, and antimicrobial resistance. Antimicrobial Agents and Chemotherapy 2016; 60(10):6115-20.
Yawei Zhang, Feifei Zhang, Hui Wang* … Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respiratory tract infections in China: results from the CARTIPS Antimicrobial Surveillance Program. Journal of Global Antimicrobial Resistance 2016; 5:36-41.
Qi Wang, Yawei Zhang, X Yao … Hui Wang* Risk factors and clinical outcomes for carbapenem-resistant Enterobacteriaceae nosocomial infections. European Journal of Clinical Microbiology & Infectious Diseases 2016; 35(10):1679-89.
Shuguang Li#, Yu Gao#, Chunjiang Zhao … Hui Wang* In vitro activities of tedizolid compared with other antibiotics against Gram-positive pathogens associated with hospital-acquired pneumonia, skin and soft tissue infection and bloodstream infection collected from 26 hospitals in China. Journal of Medical Microbiology 2016; 65(10):1215-1224.
Hongbin Chen#, Zhujia Xiong#, Kuoyue Liu# … Hui Wang* Transcriptional profiling of the two-component regulatory system VraSR in Staphylococcus aureus with low-level vancomycin resistance. International Journal of Antimicrobial Agents 2016; 47(5):362-7.

研究论文按年排序(Publications sorted by year)：

2024

2023

Yin G, Guo Y, Ding Q, Ma S, Chen F, Wang Q, Chen H, Wang H*. Klebsiella quasipneumoniae in intestine damages bile acid metabolism in hematopoietic stem cell transplantation patients with bloodstream infection. J Transl Med. 2023 Mar 29;21(1):230.

Chen H#, Zheng Y#, Zhang X, Liu S, Yin Y, Guo Y, Wang X, Zhang Y, Zhao C, Gai W*, Wang H*. Clinical evaluation of cell-free and cellular metagenomic next-generation sequencing of infected body fluids. J Adv Res. 2023 Mar 6:S2090-1232(23)00068-1.

Liu S#, Chen H#*, Chen J, Wang T, Tu S, Zhang X, Wang Q, Yin Y, Zhang Y, Wang X, Zhao C, Wang H*. Transcriptome and Proteome of Methicillin-Resistant Staphylococcus aureus Small-Colony Variants Reveal Changed Metabolism and Increased Immune Evasion. Microbiol Spectr. 2023 Feb 14:e0189822.

2022

Wang H*. Current and Future Landscape of the Antimicrobial Resistance of Nosocomial Infections in China. China CDC Wkly. 2022 Dec 9;4(49):1101-1104.

Wang Z, Fan X, Wang S, Li S, Gao Y, Wang H, Li H*. Emergence of Colistin-Resistant Acinetobacter junii in China. Antibiotics (Basel). 2022 Nov 24;11(12):1693.

Chen F, Yin Y, Chen H, Jin L, Li S, Wang R, Wang S, Wang Q, Sun S, Wang H*. Phenotypic and Genomic Comparison of Staphylococcus aureus Highlight Virulence and Host Adaptation Favoring the Success of Epidemic Clones. mSystems. 2022 Dec 20;7(6):e0083122.

Zhang P#, Wang Q#, Zhou C, Zhang F, Gao X, Tenover FC, Tang YW, Wang H*. A Pooling Strategy for Detecting Carbapenem Resistance Genes by the Xpert Carba-R Test in Rectal Swab Specimens. J Clin Microbiol. 2022 Dec 21;60(12):e0118122.

Duan Q#, Wang Q#, Sun S, Cui Q, Ding Q, Wang R, Wang H*. ST11 Carbapenem-Resistant Klebsiella pneumoniae Clone Harboring blaNDM Replaced a blaKPC Clone in a Tertiary Hospital in China. Antibiotics (Basel). 2022 Oct 7;11(10):1373.

Lo SW*, Mellor K, Cohen R, Alonso AR, Belman S, Kumar N, Hawkins PA, Gladstone RA, von Gottberg A, Veeraraghavan B, Ravikumar KL, Kandasamy R, Pollard SAJ, Saha SK, Bigogo G, Antonio M, Kwambana-Adams B, Mirza S, Shakoor S, Nisar I, Cornick JE, Lehmann D, Ford RL, Sigauque B, Turner P, Moïsi J, Obaro SK, Dagan R, Diawara I, Skoczyńska A, Wang H, Carter PE, Klugman KP, Rodgers G, Breiman RF, McGee L, Bentley SD, Muñoz-Almagro C, Varon E; Global Pneumococcal Sequencing Consortium. Emergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole-genome sequencing study. Lancet Microbe. 2022 Oct;3(10):e735-e743.

Jia Y, Zhang J, Zhao Y, Dong R, Wang H, Jiang X*. Gold nanoparticles bearing a clinically used non-antibiotic drug for combating multi-drug resistant bacteria. Chem Commun (Camb). 2022 Sep 20;58(75):10544-10547.

Wang S#, Ding Q#, Zhang Y, Zhang A, Wang Q, Wang R, Wang X, Jin L, Ma S, Wang H*. Evolution of Virulence, Fitness, and Carbapenem Resistance Transmission in ST23 Hypervirulent Klebsiella pneumoniae with the Capsular Polysaccharide Synthesis Gene wcaJ Inserted via Insertion Sequence Elements. Microbiol Spectr. 2022 Dec 21;10(6):e0240022.

Zhao C, Yang S, Zhang F, Wang Z, Zhang Y, Wang X, Li H, Chen H, Wang H*. Antimicrobial Resistance Trends of the Most Common Causative Pathogens Associated with Community-acquired Respiratory Infections in China: 2009-2018. Infect Drug Resist. 2022 Aug 31;15:5069-5083.

Chen H, Li M, Tu S, Zhang X, Wang X, Zhang Y, Zhao C, Guo Y, Wang H*. Metagenomic data from cerebrospinal fluid permits tracing the origin and spread of Neisseria meningitidis CC4821 in China. Commun Biol. 2022 Aug 18;5(1):839.
Cao LL, Han Y, Pei L, Yue ZH, Liu BY, Cui JW, Jia M, Wang H*. A Serum Metabolite Classifier for the Early Detection of Type 2 Diabetes Mellitus-Positive Hepatocellular Cancer. Metabolites. 2022 Jul 1;12(7):610.

Gao Y, Li H, Chen H, Zhang J, Wang R, Wang Z, Wang H*. Origin, Phylogeny, and Transmission of the Epidemic Clone ST208 of Carbapenem-Resistant Acinetobacter baumannii on a Global Scale. Microbiol Spectr. 2022 Jun 29;10(3):e0260421.

Wang Q, Jin L, Sun S, Yin Y, Wang R, Chen F, Wang X, Zhang Y, Hou J, Zhang Y, Zhang Z, Luo L, Guo Z, Li Z, Lin X, Bi L, Wang H*. Occurrence of High Levels of Cefiderocol Resistance in Carbapenem-Resistant Escherichia coli before Its Approval in China: a Report from China CRE-Network. Microbiol Spectr. 2022 Jun 29;10(3):e0267021.

Wang S#, Zhao C#, Yin Y, Chen F, Chen H, Wang H*. A Practical Approach for Predicting Antimicrobial Phenotype Resistance in Staphylococcus aureus Through Machine Learning Analysis of Genome Data. Front Microbiol. 2022 Mar 2;13:841289.

Zhang A, Wang X, Liang X, Zhou C, Wang Q, Zhang J, Wang H*. Performance Evaluation of Diagnostic Assays for Detection and Classification of Carbapenemase-Producing Organisms. Antibiotics (Basel). 2021 Nov 26;10(12):1457.

Mislav Acman#, Ruobing Wang, Lucy van Dorp, Liam P. Shaw, Qi Wang, Nina Luhmann, Yuyao Yin, Shijun Sun, Hongbin Chen, Hui Wang, and Francois Balloux. Role of Mobile Genetic Elements in the Global Dissemination of the Carbapenem Resistance Gene Bla(NDM). Nature Communications 2022;13(1):1131.

Jiangang Zhang#, Jinru Xie#, Henan Li, Zhiren Wang, Yuyao Yin, Shuyi Wang, Hongbin Chen, Qi Wang, and Hui Wang*. Genomic and Phenotypic Evolution of Tigecycline-Resistant Acinetobacter Baumannii in Critically Ill Patients. Microbiology Spectrum 2022;10(1):e0159321.

Shijun Sun#, Qi Wang#, Longyang Jin#, Yifan Guo, Yuyao Yin, Ruobing Wang, Lei Bi, Renfei Zhang, Yungang Han, and Hui Wang*. Identification of Multiple Transfer Units and Novel Subtypes of TmexCD-ToprJ Gene Clusters in Clinical Carbapenem-Resistant Enterobacter Cloacae and Klebsiella Oxytoca. The Journal of Antimicrobial Chemotherapy 2022;77(3):625–32.

Lin-Lin Cao, Yi Han, Yuanxiao Wang, Lin Pei, Zhihong Yue, Li Qin, Boyu Liu, Jingwen Cui, Mei Jia, and Hui Wang. Metabolic Profiling Identified a Novel Biomarker Panel for Metabolic Syndrome-Positive Hepatocellular Cancer. Frontiers in Endocrinology 2022;12:816748.

2021

Chen Z, Zhou C, Xu Y, Wen K, Song J, Bai S, Wu C, Huang W, Cai Q, Zhou K, Wang H, Wang Y, Feng X, Bai Y. An alternatingly amphiphilic, resistance-resistant antimicrobial oligoguanidine with dual mechanisms of action. Biomaterials. 2021 Aug;275:120858.

Zhiren Wang, Henan Li, Jiangang Zhang, Xiaojuan Wang, Yawei Zhang, and Hui Wang. Identification of a Novel Plasmid-Mediated Tigecycline Resistance-Related Gene, Tet(Y), in Acinetobacter Baumannii. The Journal of Antimicrobial Chemotherapy 2021;77(1):58–68.

Yawei Zhang, Xiaojuan Wang, Shifu Wang, Shijun Sun, Henan Li, Hongbin Chen, Qi Wang, and Hui Wang*. Emergence of Colistin Resistance in Carbapenem-Resistant Hypervirulent Klebsiella Pneumoniae Under the Pressure of Tigecycline. Frontiers in Microbiology 2021;12:756580.Yifan Guo, Lijuan Li, Zhenzhong Li, Lingxiao Sun, and Hui Wang*. Tropheryma Whipplei Detection by Nanopore Sequencing in Patients With Interstitial Lung Disease. Frontiers in Microbiology 2021;12:760696.

Anru Zhang, Xiaojuan Wang, Xinyue Liang, Chaoe Zhou, Qi Wang, Jiangang Zhang, and Hui Wang*. Performance Evaluation of Diagnostic Assays for Detection and Classification of Carbapenemase-Producing Organisms. Antibiotics (Basel, Switzerland) 2021;10(12).

Yifan Guo#, Henan Li#, Hongbin Chen, Zhenzhong Li, Wenchao Ding, Jun Wang, Yuyao Yin, Longyang Jin, Shijun Sun, Chendi Jing, and Hui Wang*. Metagenomic Next-Generation Sequencing to Identify Pathogens and Cancer in Lung Biopsy Tissue. EBioMedicine 2021;73:103639.

Hongbin Chen#, Yuyao Yin#, Lucy van Dorp#*, Liam P. Shaw, Hua Gao, Mislav Acman, Jizhen Yuan, Fengning Chen, Shijun Sun, Xiaojuan Wang, Shuguang Li, Yawei Zhang, Rhys A. Farrer, Hui Wang*, and Francois Balloux*. Drivers of Methicillin-Resistant Staphylococcus Aureus (MRSA) Lineage Replacement in China. Genome Medicine 2021;13(1):171.

Zhiren Wang, Henan Li*, Jiangang Zhang, and Hui Wang*. 2021. Co-Occurrence of Bla(OXA-23) in the Chromosome and Plasmid: Increased Fitness in Carbapenem-Resistant Acinetobacter Baumannii. Antibiotics (Basel, Switzerland) 2021;10(10).

Henan Li, Jiangang Zhang, Zhiren Wang, Yuyao Yin, Hua Gao, Ruobing Wang, Longyang Jin, Qi Wang, Chunjiang Zhao, Zhanwei Wang, and Hui Wang*. Evolution of Acinetobacter Baumannii in Clinical Bacteremia Patients. Infection and Drug Resistance 2021;14:3553–62.

Chendi Jing#, Hongbin Chen#, Yong Liang#, Ying Zhong, Qi Wang*, Lifeng Li, Shijun Sun, Yifan Guo, Ruobing Wang, Zhi Jiang*, and Hui Wang*. Clinical Evaluation of an Improved Metagenomic Next-Generation Sequencing Test for the Diagnosis of Bloodstream Infections. Clinical Chemistry 2021;67(8):1133–43.

Yuanxiao Wang, Lin Pei, Zhihong Yue, Mei Jia, Hui Wang, and Lin-Lin Cao. The Potential of Serum Exosomal Hsa_circ_0028861 as the Novel Diagnostic Biomarker of HBV-Derived Hepatocellular Cancer. Frontiers in Genetics 2021;12:703205.

Chendi Jing, Chenghua Liu, Yu Liu, Ruli Feng, Run Cao, Zhangchun Guan, Bo Xuan … Hui Wang*. Antibodies Against Pseudomonas Aeruginosa Alkaline Protease Directly Enhance Disruption of Neutrophil Extracellular Traps Mediated by This Enzyme. Frontiers in Immunology 2021;12:654649.

Chaoe Zhou, Longyang Jin, Qi Wang, Xiaojuan Wang, Fengning Chen, Yue Gao, Chunjiang Zhao, Hongbin Chen, Bin Cao, and Hui Wang*. Bloodstream Infections Caused by Carbapenem-Resistant Enterobacterales: Risk Factors for Mortality, Antimicrobial Therapy and Treatment Outcomes from a Prospective Multicenter Study. Infection and Drug Resistance 2021;14:731–42.

Yuyao Yin, Chunjiang Zhao, Henan Li, Longyang Jin, Qi Wang, Ruobing Wang, Yawei Zhang, Jiangang Zhang, Hui Wang*, and CARES network. Clinical and Microbiological Characteristics of Adults with Hospital-Acquired Pneumonia: A 10-Year Prospective Observational Study in China. European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology 2021;40(4):683-690.

Longyang Jin, Ruobing Wang, Hua Gao, Qi Wang, Hui Wang*. Identification of a Novel Hybrid Plasmid Encoding KPC-2 and Virulence Factors in Klebsiella pneumoniae Sequence Type 11. Antimicrobial Agents and Chemotherapy 2021;65(6):e02435-20.

Bai S#, Wang J#, Yang K#, Zhou C, Xu Y, Song J, Gu Y, Chen Z, Wang M, Shoen C, Andrade B, Cynamon M, Zhou K, Wang H, Cai Q, Oldfield E, Zimmerman SC, Bai Y*, Feng X*. A polymeric approach toward resistance-resistant antimicrobial agent with dual-selective mechanisms of action. Sci Adv. 2021 Jan 27;7(5):eabc9917.

Longyang Jin, Chunjiang Zhao, Henan Li, Ruobing Wang, Qi Wang, Hui Wang*. Clinical Profile, Prognostic Factors, and Outcome Prediction in Hospitalized Patients With Bloodstream Infection: Results From a 10-Year Prospective Multicenter Study. Frontiers in Medicine 2021;8:629671.

2020

Yawei Zhang, Chunjiang Zhao, Qi Wang … Hui Wang*. Evaluation of the in vitro activity of new polymyxin B analogue SPR206 against clinical MDR, colistin-resistant and tigecycline-resistant Gram-negative bacilli. Journal of Antimicrobial Chemotherapy 2020; 75(9):2609-2615.

Yawei Zhang, Longyang Jin, Pengwen Ouyang … Hui Wang*. Evolution of hypervirulence in carbapenem-resistant Klebsiella pneumoniae in China: a multicentre, molecular epidemiological analysis. Journal of Antimicrobial Chemotherapy 2020; 75(2):327-336.

Xiaojuan Wang, Chunjiang Zhao, Qi Wang … Hui Wang*. In vitro activity of the novel β-lactamase inhibitor taniborbactam (VNRX-5133), in combination with cefepime or meropenem, against MDR Gram-negative bacterial isolates from China. Journal of Antimicrobial Chemotherapy 2020; 75(7):1850-1858.

Qi Wang, Zhanwei Wang, Feifei Zhang … Hui Wang*. Long-term continuous antimicrobial resistance surveillance among nosocomial Gram-negative bacilli in China from 2010 to 2018 (CMSS). Infection and Drug Resistance 2020; 13:2617-2629.

Kaiying Wang#, Peihan Li#, Yanfeng Lin# … Peng Li*, Hui Wang*, Hongbin Song* Metagenomic diagnosis for a culture-negative sample from a patient with severe pneumonia by nanopore and next-generation sequencing. Frontiers in Cellular and Infection Microbiology 2020; 10:182.

Yudong Liu, Qi Wang, Chunjiang Zhao … Hui Wang*. Prospective multi-center evaluation on risk factors, clinical characteristics and outcomes due to carbapenem resistance in Acinetobacter baumannii complex bacteraemia: experience from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) Network. Journal of Medical Microbiology 2020; 69(7):949-959.

Shijun Sun#, Hua Gao#, Yudong Liu# … Hui Wang* .Co-existence of a novel plasmid-mediated efflux pump with colistin resistance gene mcr in one plasmid confers transferable multidrug resistance in Klebsiella pneumonia. Emerging Microbes & Infections 2020; 9(1):1102-1113.

Shuguang Li#, Liyan Lin#, Feifei Zhang … Hui Wang* .A retrospective study on Xpert MTB/RIF for detection of tuberculosis in a teaching hospital in China. BMC Infectious Diseases 2020; 20(1):362.

Longyang Jin, Yudong Liu, Chendi Jing … Hui Wang*. Neutrophil extracellular traps (NETs)-mediated killing of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) are impaired in patients with diabetes mellitus. Virulence 2020; 11(1):1122-1130.

Hua Gao#, Yudong Liu#, Ruobing Wang# … Hui Wang*. The transferability and evolution of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings. EBioMedicine 2020; 51:102599.

Hongbin Chen, Yuyao Yin, Xiaohua Li … Hui Wang* .Whole-genome analysis of livestock-associated methicillin-resistant Staphylococcus aureus sequence type 398 strains isolated from patients with bacteremia in China. Journal of Infectious Diseases 2020; 221(Supplement_2):S220-S228.

2019

Yuyao Yin, Hongbin Chen, Shuguang Li … Hui Wang* . Daptomycin resistance in methicillin-resistant Staphylococcus aureus is conferred by IS256 insertion in the promoter of mprF along with mutations in mprF and walK. International Journal of Antimicrobial Agents 2019; 54(6):673-680.

Xiaojuan Wang#, Qi Wang#, Bin Cao … Hui Wang* . Retrospective observational study from a Chinese network of the impact of combination therapy versus monotherapy on mortality from carbapenem-resistant Enterobacteriaceae bacteremia. Antimicrobial Agents and Chemotherapy 2019; 63(1):e01511-18.

Lucy van Dorp#*, Qi Wang#, Liam P Shaw … Francois Balloux*, Hui Wang* . Rapid phenotypic evolution in multidrug-resistant Klebsiella pneumoniae hospital outbreak strains. Microbial Genomics 2019; 5(4):e000263.

Yi Shi#, Yi Huang#, Tian-Tuo Zhang#, Bin Cao#, Hui Wang# … Jie-Ming Qu*. Chinese guidelines for the diagnosis and treatment of hospital-acquired pneumonia and ventilator-associated pneumonia in adults (2018 Edition). Journal of Thoracic Disease 2019; 11(6):2581-2616.

Hongbin Chen#, Xiaojuan Wang#, Yuyao Yin … Hui Wang*. Molecular characteristics of oxazolidinone resistance in enterococci from a multicenter study in China. BMC Microbiology 2019; 19(1):162.

2018

Yawei Zhang#, Qi Wang#, Yuyao Yin … Hui Wang*. Epidemiology of carbapenem-resistant Enterobacteriaceae infections: report from the China CRE Network. Antimicrobial Agents and Chemotherapy 2018; 62(2):e01882-17.

Zhao X#, Jia Y#, Li J, Dong R, Zhang J, Ma C, Wang H, Rui Y*, Jiang X*. Indole Derivative-Capped Gold Nanoparticles as an Effective Bactericide in Vivo. ACS Appl Mater Interfaces. 2018 Sep 5;10(35):29398-29406.

Jiangang Zhang, Chunjiang Zhao, Hongbin Chen … Hui Wang*. A multicenter epidemiology study on the risk factors and clinical outcomes of nosocomial intra-abdominal infections in China: results from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) 2007-2016. Infection and Drug Resistance 2018; 11:2311-2319.

Zhi-hong Yue#, Chang-sheng Xia#, Hui Wang*. Performance evaluation of the mindray anti-HCV assay for the detection of hepatitis C virus infection. Journal of Clinical Laboratory Analysis 2018; 32(9):e22600.

Chang-Sheng Xia*, Zhi-Hong Yue*, Hui Wang*. Evaluation of three automated Treponema pallidum antibody assays for syphilis screening. Journal of Infection and Chemotherapy 2018; 24(11):887-891.

Xiaojuan Wang#, Jian Bing#, Qiushi Zheng# … Hui Wang*, Guanghua Huang*. The first isolate of Candida auris in China: clinical and biological aspects. Emerging Microbes & Infections 2018; 7(1):93.

Ruobing Wang#, Lucy van Dorp#, Liam P Shaw# … Hui Wang*, Francois Balloux* . The global distribution and spread of the mobilized colistin resistance gene mcr-1. Nature Communications 2018; 9(1):1179.

Ruobing Wang#, Yuqing Liu#, Qing Zhang … Hui Wang*. The prevalence of colistin resistance in Escherichia coli and Klebsiella pneumoniae isolated from food animals in China: coexistence of mcr-1 and blaNDM with low fitness cost. International Journal of Antimicrobial Agents 2018; 51(5):739-744.

Qi Wang#, Xiaojuan Wang#, Juan Wang … Hui Wang*. Phenotypic and genotypic characterization of carbapenem-resistant Enterobacteriaceae: data from a longitudinal large-scale CRE study in China (2012-2016). Clinical Infectious Diseases 2018; 67(suppl_2):S196-S205.

Chen Liu*, Dongwei Wang, Ying Song … Hui Wang*. Increased circulating CD4+ CXCR5+ FoxP3+ follicular regulatory T cells correlated with severity of systemic lupus erythematosus patients. International Immunopharmacology 2018; 56:261-268.

Shuguang Li, Shijun Sun, Chentao Yang … Hui Wang*. The changing pattern of population structure of Staphylococcus aureus from bacteremia in China from 2013 to 2016: ST239-030-MRSA replaced by ST59-t437. Frontiers in Microbiology 2018; 9:332.

Henan Li, Hua Gao, Han Meng … Hui Wang*. Detection of pulmonary infectious pathogens from lung biopsy tissues by metagenomic next-generation sequencing. Frontiers in Cellular and Infection Microbiology 2018; 8:205.

Longyang Jin#, Ruobing Wang#, Xiaojuan Wang … Hui Wang*. Emergence of mcr-1 and carbapenemase genes in hospital sewage water in Beijing, China. Journal of Antimicrobial Chemotherapy 2018; 73(1):84-87.

Chunmei Jin#, Jiangang Zhang#, Qi Wang … Hui Wang*. Molecular characterization of carbapenem-resistant Enterobacter cloacae in 11 Chinese cities. Frontiers in Microbiology 2018; 9:1597.

Hongbin Chen, Qi Wang, Yuyao Yin … Deng-Ke Niu*, Hui Wang*. Genotypic variations between wild-type and small colony variant of Staphylococcus aureus in prosthetic valve infectious endocarditis: a comparative genomic and transcriptomic analysis. International Journal of Antimicrobial Agents 2018, 51(4):655-658.

更早

Chunjiang Zhao#, Zongbo Li#, Feifei Zhang … Hui Wang*. Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolates from 17 Chinese cities from 2011 to 2016. BMC Infectious Diseases 2017; 17(1):804.

Yawei Zhang#, Kang Liao#, Hua Gao# … Hui Wang*. Decreased fitness and virulence in ST10 Escherichia coli harboring blaNDM-5 and mcr-1 against a ST4981 strain with blaNDM-5. Frontiers in Cellular and Infection Microbiology 2017; 7:242.

Xiaojuan Wang#, Yuqing Liu#, Xiaomei Qi … Hui Wang*. Molecular epidemiology of colistin-resistant Enterobacteriaceae in inpatient and avian isolates from China: high prevalence of mcr-negative Klebsiella pneumonia. International Journal of Antimicrobial Agents 2017; 50(4):536-541.

Ruobing Wang, Xuebin Li, Qi Wang … Hui Wang*. Microbiological characteristics and clinical features of cardiac implantable electronic device infections at a tertiary hospital in China. Frontiers in Microbiology 2017; 8:360.

Chen Liu*, Lei Zhao, Jingzhong Zhao … Hui Wang*. Decreased ADAMTS-13 level is related to inflammation factors and risk stratification of acute lymphoblastic leukemia patients. Medicine 2017; 96(7):e6136.

Chen Liu, Lei Zhao, Jingzhong Zhao … Hui Wang*. Reduced ADAMTS-13 level negatively correlates with inflammation factors in plasma of acute myeloid leukemia patients. Leukemia Research 2017; 53:57-64.

Shuguang Li#, Yuyao Yin#, Hongbin Chen … Hui Wang*. Fitness cost of daptomycin-resistant Staphylococcus aureus obtained from in vitro daptomycin selection pressure. Frontiers in Microbiology 2017; 8:2199.

Henan Li, Qi Wang, Ruobing Wang … Hui Wang*. Global regulator SoxR is a negative regulator of efflux pump gene expression and affects antibiotic resistance and fitness in Acinetobacter baumannii. Medicine 2017; 96(24):e7188.

Yawei Zhang, Chunjiang Zhao, Qi Wang … Hui Wang*. High prevalence of hypervirulent Klebsiella pneumoniae infection in China: geographic distribution, clinical characteristics, and antimicrobial resistance. Antimicrobial Agents and Chemotherapy 2016; 60(10):6115-20.

Yawei Zhang, Feifei Zhang, Hui Wang* … Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respiratory tract infections in China: results from the CARTIPS Antimicrobial Surveillance Program. Journal of Global Antimicrobial Resistance 2016; 5:36-41.

Qi Wang, Yawei Zhang, X Yao … Hui Wang*. Risk factors and clinical outcomes for carbapenem-resistant Enterobacteriaceae nosocomial infections. European Journal of Clinical Microbiology & Infectious Diseases 2016; 35(10):1679-89.

Shuguang Li#, Yu Gao#, Chunjiang Zhao … Hui Wang*. In vitro activities of tedizolid compared with other antibiotics against Gram-positive pathogens associated with hospital-acquired pneumonia, skin and soft tissue infection and bloodstream infection collected from 26 hospitals in China. Journal of Medical Microbiology 2016; 65(10):1215-1224.

Hongbin Chen#, Zhujia Xiong#, Kuoyue Liu# … Hui Wang*. Transcriptional profiling of the two-component regulatory system VraSR in Staphylococcus aureus with low-level vancomycin resistance. International Journal of Antimicrobial Agents 2016;47(5):362-7.

国际标准和亚太指南：

CLSI M07: Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically 参与制定

CLSI M100: Performance Standards for Antimicrobial Susceptibility Testing 参与制定

CLSI M02: Performance Standards for Antimicrobial Disk Susceptibility Tests 参与制定

APEC Guideline to Tackle Antimicrobial Resistance in the Asia-Pacific Region 参与制定

行业标准：

2022年 WS/T 807-2022 临床微生物培养、鉴定和药敏检测系统的性能验证主要起草人

2018年 WS/T 639-2018 抗菌药物敏感性试验技术要求主持修订

2018年 WS/T 640-2018 临床微生物学检验标本的采集和转运主持制定

2017年 WS/T 499-2017 下呼吸道感染细菌培养操作指南主要起草人

2013年 WS/T 411-2013 抗丝状真菌药物敏感性试验肉汤稀释法主要起草人

2013年 WS/T 421-2013 抗酵母样真菌药物敏感性试验肉汤稀释法主要起草人

临床指南：

中华医学会呼吸病学分会感染学组. 中国成人医院获得性肺炎与呼吸机相关性肺炎诊断和治疗指南(2018年版)[J]. 中华结核和呼吸杂志, 2018, 41(4):255-280.

中国侵袭性真菌感染工作组. 血液病/恶性肿瘤患者侵袭性真菌病的诊断标准与治疗原则(第五次修订版)[J]. 中华内科杂志, 2017, 56(006):453-459.

中华医学会呼吸病学分会.中国成人社区获得性肺炎诊断和治疗指南(2016年版)[J].中华结核和呼吸杂志,2016,39(4):253-279.

中华医学会儿科学分会,中华预防医学会.儿童肺炎链球菌性疾病防治技术指南(2009年版)[J].中华儿科杂志,2010,48(2):104-111.

专家共识：

中国医疗保健国际交流促进会临床微生物与感染分会,中华医学会检验医学分会临床微生物学组,中华医学会微生物学和免疫学分会临床微生物学组.血液培养技术用于血流感染诊断临床实践专家共识[J].中华检验医学杂志, 2022, 45(2):17. 专家组成员通讯作者

中华医学会检验医学分会临床微生物学组,中华医学会微生物学与免疫学分会临床微生物学组,中国医疗保健国际交流促进会临床微生物与感染分会.宏基因组高通量测序技术应用于感染性疾病病原检测中国专家共识[J].中华检验医学杂志,2021,44(2):107-120. 专家组成员通讯作者

中国医疗保健国际交流促进会临床微生物与感染分会,中华医学会检验医学分会临床微生物学组,中华医学会微生物学与免疫学分会临床微生物学组.多黏菌素类与替加环素及头孢他啶/阿维巴坦药敏方法和报告专家共识[J].中华检验医学杂志,2020,43(10):964-972. 主持通讯作者

中华医学会检验医学分会.新型冠状病毒肺炎临床实验室生物安全防护专家共识[J].中华检验医学杂志,2020,43(3):203-208. 主持共同通讯作者

中华医学会检验分会临床微生物学学组.成人耳念珠菌感染诊治防控专家共识[J].临床检验杂志,2020,38(8):564-570.主持通讯作者

王辉,马筱玲,宁永忠,等.细菌与真菌涂片镜检和培养结果报告规范专家共识[J].中华检验医学杂志,2017,40(1):17-30. 主持通讯作者

中国医师协会检验医师分会.导管相关性血流感染检验诊断报告模式专家共识[J].中华医学杂志,2017,97(18):1376-1379. 主持通讯作者

王辉,宁永忠,陈宏斌,等.常见细菌药物敏感性试验报告规范中国专家共识[J].中华检验医学杂志,2016,(1):18-22. 主持通讯作者

王辉,俞云松,王明贵,等.替加环素体外药敏试验操作规程专家共识[J].中华检验医学杂志,2013,36(7):584-587. 主持通讯作者

陈佰义,何礼贤,胡必杰,等.中国鲍曼不动杆菌感染诊治与防控专家共识[J].中国医药科学,2012,02(8):3-8. 共同发起人共同作者

国家发明专利：

2015年一种检测革兰氏阴性细菌耐药基因的基因芯片试剂盒（专利号：ZL201510941253.3）
2022年一种病原微生物鉴定方法（专利号：ZL202210344311.4）

论著：

王辉；马筱玲；钱渊；李若瑜；曹建平；史红，临床微生物学手册（第11版）（中译本），中华医学电子音像出版社，2017

王辉；任健康；王明贵，《临床微生物学检验》，人民卫生出版社，2015

奖励：

2023年第十届国家卫生健康突出贡献中青年专家

2019年中国实验医学杰出青年奖

2019年五洲女子科技奖

2018年国之名医·优秀风范

2018年华夏医学科技三等奖（第一完成人）

2018年中华医学科技进步三等奖（第一完成人）

2011年教育部新世纪优秀人才

2006年国家科技进步二等奖（第三完成人）

2006年北京市科技新星

2002年中华医学科技进步二等奖（第二完成人）

学生荣誉：

博（硕）士研究生国家奖学金：贺文强（2013）、王晓娟（2014）、张雅薇（2015；2016）、王若冰（2017；2018）、尹玉瑶（2019）、靳龙阳（2018）

国家建设高水平大学公派研究生项目：张雅薇（2017）、尹玉瑶（2020）

北京大学医学部博士研究生短期出国(境)研究项目：王若冰（2019）

北京大学医学部优秀博士生创新基金：王若冰（2018）、靳龙阳（2021）

北京大学医学部博士研究生创新人才：靳龙阳（2021）

北京市优秀毕业生：贺文强（2014）、王晓娟（2015）、王若冰（2020）、尹玉瑶（2021）、靳龙阳（2022）

北京大学优秀博士学位论文：王晓娟（2015）、孙世俊（2023）

北京大学优秀毕业生：贺文强（2014）、王晓娟（2015）、张雅薇（2018）、王若冰（2020）、张建港（2020）、尹玉瑶（2021）、靳龙阳（2022）、王知任（2023）、刘思（2024）

北京大学创新奖（学术类）：王晓娟（2014）、张雅薇（2016）、王若冰（2017；2018）、靳龙阳（2018）

北京大学三好学生标兵：张雅薇（2016）、王若冰（2017；2018）、尹玉瑶（2019）、靳龙阳（2018）

北京大学三好学生：贺文强（2013）、张雅薇（2015）、尹玉瑶（2018）、周朝娥（2019）、尹玉瑶（2020）、高悦（2022）、郑绩（2024）

北京大学优秀医学研究生二等奖（卓越）：尹玉瑶（2018）、尹玉瑶（2020）

北京大学优秀医学生二等奖：张建港（2019）、郑绩（2024）

北京大学学习优秀奖：张雅薇（2017）、尹玉瑶（2017）、孙世俊（2019）、王若冰（2019）

北京大学优秀医学生三等奖：王若冰（2019）、周朝娥（2019）、高悦（2022）

北京大学实践公益奖：郑绩（2024）

Wang Hui's Lab

研究成果 (Research findings)

研究论文 (Publications)：

研究论文 按年排序(Publications sorted by year)：

国际标准和亚太指南：

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